The Influence of Mucin-Based Artificial Saliva on Properties of Polycaprolactone and Polylactide
Dawid Łysik , Joanna Mystkowska , Grzegorz Markiewicz , Piotr Deptuła , Robert Bucki
AbstractPolycaprolactone (PCL) and polylactide (PLA) are the two most common biodegradable polymers with potential use in oral applications. Both polymers undergo mainly slow hydrolytic degradation in the human body. However, specific conditions of the oral cavity, like elevated temperature, low pH, and presence of saliva affect the rate of hydrolysis. The study examined the properties of solid samples of PCL and PLA subjected to degradation in phosphate buffered saline (PBS) and artificial saliva (AS) at temperatures of 37 or 42 °C, and pH values 2 or 7.4. A number of tests were performed, including measurement of the degree of swelling, weight loss, molecular weight, differential scanning calorimetry, and thermogravimetry of polymers, as well as hardness and tensile strength. Additionally, topography and stiffness of surfaces using atomic force microscopy are presented. It has been noticed that in the artificial saliva, the processes of polymer degradation occur slightly more slowly, and the effects of temperature and pH are less pronounced. We believe that a layer of porcine gastric mucin from artificial saliva that adsorbed on the surface of polymers may have a key role in the observed differences; this layer resembles protective mucin coating tissues in the oral cavity.
|Journal series||Polymers, ISSN 2073-4360, (N/A 100 pkt)|
|Publication size in sheets||0.9|
|Keywords in English||degradation, saliva, mechanical properties, molecular weight, thermal properties, activation energy of thermal decomposition|
|Internal identifier||ROC 19-20|
|License||Journal (articles only); published final; ; with publication|
|Score||= 100.0, 11-03-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 1.057; : 2017 = 2.935 (2) - 2017=3.509 (5)|
|Citation count*||1 (2020-04-06)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.