Toxicological Effects of Traumatic Acid and Selected Herbicides on Human Breast Cancer Cells: In Vitro Cytotoxicity Assessment of Analyzed Compounds

Agata Jabłońska-Trypuć , Urszula Wydro , Elżbieta Wołejko , Andrzej Butarewicz

Abstract

The main consequence of herbicides use is the presence of their residues in food of plant origin. A growing body of evidence indicates that herbicides cause detrimental effects upon human health while demonstrating a direct link of pesticides exposure with the occurrence of human chronic diseases, including cancer. There is a pressing need to develop our knowledge regarding interactions of food contaminants and food components both in vitro and in vivo. Pesticides are highly undesirable food contaminants, and traumatic acid (TA) is a very beneficial food ingredient, therefore we decided to study if TA may act as a compound that delays the stimulatory effect of pesticides on breast cancer cells. To analyze the potential effects that selected herbicides (MCPA, mesotrione, bifenox and dichlobenil) may have upon cancerous cells, we conducted studies of the cytotoxicity of physiological concentrations of four pesticides and the mix of TA with tested herbicides in three different breast cancer cell lines (MCF-7, ZR-75-1 and MDA-MB-231) and one normal healthy breast cell line MCF-12A. Based on the obtained results we conclude that TA in a concentration-dependent manner might influence selected effects of the studied herbicides for particular cancer cells lines.
Author Agata Jabłońska-Trypuć (FCEE / DCBB)
Agata Jabłońska-Trypuć,,
- Department of Chemistry, Biology and Biotechnology
, Urszula Wydro (FCEE / DCBB)
Urszula Wydro,,
- Department of Chemistry, Biology and Biotechnology
, Elżbieta Wołejko (FCEE / DCBB)
Elżbieta Wołejko,,
- Department of Chemistry, Biology and Biotechnology
, Andrzej Butarewicz (FCEE / DCBB)
Andrzej Butarewicz,,
- Department of Chemistry, Biology and Biotechnology
Journal seriesMolecules, ISSN 1420-3049, (N/A 100 pkt)
Issue year2019
Vol24
No9
Pages1-21
Publication size in sheets1
Keywords in Englishherbicide, breast cancer, mixture toxicity, cytotoxicity, traumatic acid
ASJC Classification1605 Organic Chemistry
DOIDOI:10.3390/molecules24091710
URL https://www.mdpi.com/1420-3049/24/9/1710
Internal identifier000045392
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)100
Score sourcejournalList
ScoreBUT score = 36.0
Ministerial score = 100.0, 06-03-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.146; WoS Impact Factor: 2018 = 3.06 (2) - 2018=3.38 (5)
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