Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia

Karol Charkiewicz , Joanna Gościk , Grzegorz Raba , Piotr Laudanski

Abstract

Introduction: Preeclampsia has the highest rate of obstetric morbidity and mortality. Methods: We recruited 21 women with preeclampsia and 27 women with uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis of 40 proteins. Results: We found a statistically significant increase in the concentration of DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in the plasma of women with preeclampsia. Conclusions: There are no previous studies assessing syndecan 4, galectin 2, and DR3 concentrations in women with preeclampsia; Our results indicate these proteins are new factors that play important roles in the immunological pathomechanism of preeclampsia.
Author Karol Charkiewicz
Karol Charkiewicz,,
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, Joanna Gościk (FCS / SD)
Joanna Gościk,,
- Software Department
, Grzegorz Raba
Grzegorz Raba,,
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, Piotr Laudanski
Piotr Laudanski,,
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Journal seriesJournal of Maternal-Fetal & Neonatal Medicine, [Journal of Maternal-Fetal and Neonatal Medicine], ISSN 1476-7058, e-ISSN 1476-4954, (N/A 70 pkt)
Issue year2019
Vol32
Pages1-6
Publication size in sheets0.5
Keywords in EnglishAngiogenesis; apoptosis; cytokine; immune response; inflammatory factors; placenta; preeclampsia
ASJC Classification2729 Obstetrics and Gynaecology; 2735 Pediatrics, Perinatology, and Child Health
DOIDOI:10.1080/14767058.2019.1676410
Internal identifierROC 19-20
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 12-02-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.663; WoS Impact Factor: 2018 = 1.569 (2) - 2018=1.601 (5)
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