Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia
Karol Charkiewicz , Joanna Gościk , Grzegorz Raba , Piotr Laudanski
AbstractIntroduction: Preeclampsia has the highest rate of obstetric morbidity and mortality. Methods: We recruited 21 women with preeclampsia and 27 women with uncomplicated pregnancies. We used a quantitative protein macroarray that allowed for analysis of 40 proteins. Results: We found a statistically significant increase in the concentration of DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in the plasma of women with preeclampsia. Conclusions: There are no previous studies assessing syndecan 4, galectin 2, and DR3 concentrations in women with preeclampsia; Our results indicate these proteins are new factors that play important roles in the immunological pathomechanism of preeclampsia.
|Journal series||Journal of Maternal-Fetal & Neonatal Medicine, [Journal of Maternal-Fetal and Neonatal Medicine], ISSN 1476-7058, e-ISSN 1476-4954, (N/A 70 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Angiogenesis; apoptosis; cytokine; immune response; inflammatory factors; placenta; preeclampsia|
|Internal identifier||ROC 19-20|
|Score||= 70.0, 12-02-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 0.663; : 2018 = 1.569 (2) - 2018=1.601 (5)|
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