Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

Dawid Łysik , Katarzyna Niemirowicz-Laskowska , Robert Bucki , Grażyna Tokajuk , Joanna Mystkowska

Abstract

The chronic sensation of a dry mouth is a disease condition called xerostomia and affects a large part of the population. Xerostomia is associated with decreased secretion, or more often, qualitative changes in saliva proteins and immunoglobulin concentrations that develop as a result of salivary gland dysfunction. Several reasons causing dry mouth were described, and usually, they include taking medications, diseases or radiotherapy. In some situations, when it is difficult to use salivary stimulants or salivary gland damage is irreversible, the only option might seem to be saliva substitutes. The paper presents the most important aspects considering saliva preparations. The rheological and lubricating properties and the reconstruction of the complex saliva structure has been the main purpose of research. The biological properties of saliva preparations were also widely discussed. As part of the work, the antimicrobial effect of three commercial saliva preparations was tested. Finally, inadequate antimicrobial properties against the strains isolated from the oral cavity were demonstrated. The development of salivary substitutes, in particular, the improvement of antimicrobial properties, can be achieved using nanotechnology, including drug delivery systems containing nanocarriers.
Author Dawid Łysik (FME / DMPE)
Dawid Łysik,,
- Department of Material and Production Engineering
, Katarzyna Niemirowicz-Laskowska
Katarzyna Niemirowicz-Laskowska,,
-
, Robert Bucki
Robert Bucki,,
-
, Grażyna Tokajuk
Grażyna Tokajuk,,
-
, Joanna Mystkowska (FME / DMPE)
Joanna Mystkowska,,
- Department of Material and Production Engineering
Journal seriesInternational Journal of Molecular Sciences, ISSN 1422-0067, (N/A 140 pkt)
Issue year2019
Vol20
No13
Pages1-17
Publication size in sheets0.8
Keywords in Englishartificial saliva, xerostomia, rheology
ASJC Classification2700 General Medicine; 1312 Molecular Biology; 1503 Catalysis; 1604 Inorganic Chemistry; 1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry; 1607 Spectroscopy; 1706 Computer Science Applications
DOIDOI:10.3390/ijms20133199
URL https://www.mdpi.com/1422-0067/20/13/3199
Internal identifierROC 19-20
Languageen angielski
LicenseJournal (articles only); published final; Uznanie Autorstwa (CC-BY); with publication
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 25-03-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.224; WoS Impact Factor: 2018 = 4.183 (2) - 2018=4.331 (5)
Citation count*3 (2020-04-08)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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