Curcumin as tyrosine kinase inhibitor in cancer treatment

Aleksandra Golonko , Hanna Lewandowska , Renata Świsłocka , Urszula Jasińska , Waldemar Priebe , Włodzimierz Lewandowski

Abstract

Curcumin is a natural substance known for ages, exhibiting a multidirectional effect in cancer prevention and adjuvant cancer therapies. The great advantage of using nutraceuticals of vegetable origin in comparison to popular cytostatic drugs is the minimized side effect and reduced toxicity. The targets in oncological therapy are, among others, tyrosine kinases, important mediators of signaling pathways whose impaired expression is observed in many types of cancer. Unfortunately, the hydrophobic nature of the curcumin molecule often limits its bioavailability, which is why many studies focus on the chemical modification of this compound. Current research is aimed at modifying structures that improve the pharmacokinetic parameters of curcumin, e.g. the formation of nanoparticles, complexes with metals or the synthesis of curcumin derivatives with functional substituents that allow tumor targeting. The article is a review and analysis of current literature on the properties of curcumin and its derivatives in the treatment of cancers directed to signaling pathways of tyrosine kinases and confronts the problem of low assimilation of curcumin with potential therapeutic effects
Author Aleksandra Golonko
Aleksandra Golonko,,
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, Hanna Lewandowska
Hanna Lewandowska,,
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, Renata Świsłocka (FCEE / DCBB)
Renata Świsłocka,,
- Department of Chemistry, Biology and Biotechnology
, Urszula Jasińska
Urszula Jasińska,,
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, Waldemar Priebe
Waldemar Priebe,,
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, Włodzimierz Lewandowski (FCEE / DCBB)
Włodzimierz Lewandowski,,
- Department of Chemistry, Biology and Biotechnology
Journal seriesEuropean Journal of Medicinal Chemistry, ISSN 0223-5234, e-ISSN 1768-3254, (N/A 140 pkt)
Issue year2019
Vol181
Pages1-25
Publication size in sheets1.2
Keywords in EnglishTyrosine kinases, Curcumin, Nanoparticles, Complexes, Growth factors, Cancer therapy
ASJC Classification2700 General Medicine; 3002 Drug Discovery; 3004 Pharmacology; 1605 Organic Chemistry
DOIDOI:10.1016/j.ejmech.2019.07.015
URL https://www.sciencedirect.com/journal/european-journal-of-medicinal-chemistry/vol/181/suppl/C
Internal identifierROC 19-20
Languageen angielski
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 12-02-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.464; WoS Impact Factor: 2018 = 4.833 (2) - 2018=4.666 (5)
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