The Analysis of Bifenox and Dichlobenil Toxicity in Selected Microorganisms and Human Cancer Cells

Agata Jabłońska-Trypuć , Urszula Wydro , Lluis Serra-Majem , Elżbieta Wołejko , Andrzej Butarewicz

Abstract

Bifenox and Dichlobenil belong to the commonly used in Poland in agriculture group of herbicides and their residues are often detected in the environment. They are poorly known regarding their possible carcinogenic and antibacterial effect at the cellular level. Therefore, we decided to study their activity in bacterial strains Aliivibrio fisheri, E. coli, P. aeruginosa, and C. albicans (yeast) and human cancer ZR-75-1 cells. Compounds under study exhibit stimulatory effect on analyzed bacterial strains. The study performed on mammalian cells better reflects the influence of environmental pollutants on human organism, therefore we evaluated the effect of herbicides on ZR-75-1 cells. Cells viability, apoptosis and selected oxidative stress parameters in ZR-75-1 cells were investigated. Both analyzed substances exhibit stimulatory effects on analyzed parameters, however they do not stimulate apoptosis which correlate positively with the induction of oxidative stress. Bifenox and Dichlobenil enhance oxidative stress parameters by the generation of high levels of ROS, which can lead to their adaptation and resistance to the standard treatment regimen.
Author Agata Jabłońska-Trypuć (FCEE/DCBB)
Agata Jabłońska-Trypuć,,
- Department of Chemistry, Biology and Biotechnology
, Urszula Wydro (FCEE/DCBB)
Urszula Wydro,,
- Department of Chemistry, Biology and Biotechnology
, Lluis Serra-Majem - [Universidad de Las Palmas de Gran Canaria]
Lluis Serra-Majem,,
-
-
, Elżbieta Wołejko (FCEE/DCBB)
Elżbieta Wołejko,,
- Department of Chemistry, Biology and Biotechnology
, Andrzej Butarewicz (FCEE/DCBB)
Andrzej Butarewicz,,
- Department of Chemistry, Biology and Biotechnology
Journal seriesInternational Journal of Environmental Research and Public Health, ISSN 1661-7827, e-ISSN 1660-4601, (N/A 70 pkt)
Issue year2019
Vol16
No21
Pages1-19
Publication size in sheets0.90
Article number4137
Keywords in Englishherbicides; bacteria; fungi; ZR-75-1 cells
ASJC Classification Public Health, Environmental and Occupational Health2739; Health, Toxicology and Mutagenesis2307
DOIDOI:10.3390/ijerph16214137
URL https://www.mdpi.com/1660-4601/16/21/4137
Internal identifierROC 19-20
Languageen angielski
LicenseUznanie Autorstwa (CC-BY)
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 27-05-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1.000; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.129; WoS Impact Factor: 2018 = 2.468 (2) - 2018=2.948 (5)
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