Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

Aleksandra Golonko , Tomasz Pieńkowski , Renata Świsłocka , Ryszard Lazny , Marek Roszko , Włodzimierz Lewandowski

Abstract

Inhibitors of the ubiquitin-proteasome system (UPS) have been the object of research interests for many years because of their potential as anti-cancer agents. Research in this field is aimed at improving the specificity and safety of known proteasome inhibitors. Unfortunately, in vitro conditions do not reflect the processes taking place in the human body. Recent reports indicate that the components of human plasma affect the course of many signaling pathways, proteasome activity and the effectiveness of synthetic cytostatic drugs. Therefore, it is believed that the key issue is to determine the effects of components of the human diet, including effects of chemically active polyphenols on the ubiquitin-proteasome system activity in both physiological and pathological (cancerous) states. The following article summarizes the current knowledge on the direct and indirect synergistic and antagonistic effects between polyphenolic compounds present in the human diet and the efficiency of protein degradation via the UPS.
Author Aleksandra Golonko
Aleksandra Golonko,,
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, Tomasz Pieńkowski
Tomasz Pieńkowski,,
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, Renata Świsłocka (FCEE / DCBB)
Renata Świsłocka,,
- Department of Chemistry, Biology and Biotechnology
, Ryszard Lazny
Ryszard Lazny,,
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, Marek Roszko
Marek Roszko,,
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, Włodzimierz Lewandowski
Włodzimierz Lewandowski,,
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Journal seriesEuropean Journal of Medicinal Chemistry, ISSN 0223-5234, (N/A 140 pkt)
Issue year2019
Vol167
Pages291-311
Publication size in sheets1
ASJC Classification1605 Organic Chemistry; 3002 Drug Discovery; 3004 Pharmacology; 2700 General Medicine
Internal identifier000044985
Languageen angielski
Score (nominal)140
Score sourcejournalList
ScoreBUT score = 48.0, 14-06-2019, manual
Ministerial score = 140.0, 12-02-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.464; WoS Impact Factor: 2018 = 4.833 (2) - 2018=4.666 (5)
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