Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome

Agnieszka Adamska , Anna Krentowska , Agnieszka Łebkowska , Justyna Hryniewicka , Monika Leśniewska , Marcin Adamski , Irina Kowalska

Abstract

Objective Glucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyroid function may affect atherosclerosis risk factors. The aim of this study was to evaluate the relationships between thyroid hormonal status and glucose and lipid profile before and after oral glucose tolerance test (OGTT) in PCOS women in comparison to the control group. Patients and methods The study group included 98 women—60 women with PCOS and 38 women matched for age and BMI as a control group. OGTT with estimation of plasma glucose and lipids, as well as serum insulin and thyroid hormones (TH) concentrations was performed. Activity of peripheral deiodinases at baseline (SPINA-GD1) and at the 120 min of OGTT (SPINA-GD2) was calculated according to the formula by Dietrich et al. as a measure of T4–T3 conversion efficiency. Delta GD was estimated as SPINA-GD1–SPINA-GD2, and delta fT3 was calculated as a difference between fT3 before and after OGTT. Results We did not find differences in TH, SPINA-GDs, and plasma lipid concentrations between PCOS and control group before and after OGTT. Glucose load resulted in a decrease of level TSH, TC, TG, HDL-C, and LDL-C concentrations in women with PCOS, as well as in the control group (all p < 0.05). We found that GD (p = 0.01) and serum fT3 concentration (p = 0.0008) decreased during glucose load only in the PCOS group. We observed a positive relationship between delta fT3 and plasma TG concentration (r = 0.36, p = 0.004), delta GD and plasma TG concentration after glucose load (r = 0.34, p = 0.007), only in the PCOS group. We also found negative relationship between SPINA-GD2 and plasma TC concentration (r = −0.29, p = 0.02) after glucose load and positive relationship between delta GD and insulin at the 60 min of OGTT (r = 0.29, p = 0.02), only in the PCOS women. Conclusions These data showed insufficient conversion of fT4 to fT3, as well as a relationship of SPINA-GDs with insulin, TC and TG in PCOS women after glucose load. It may suggest that disturbances in deiodinase activity after glucose load might promote atherosclerosis in PCOS women.
Author Agnieszka Adamska
Agnieszka Adamska,,
-
, Anna Krentowska
Anna Krentowska,,
-
, Agnieszka Łebkowska
Agnieszka Łebkowska,,
-
, Justyna Hryniewicka
Justyna Hryniewicka,,
-
, Monika Leśniewska
Monika Leśniewska,,
-
, Marcin Adamski (FCS / SD)
Marcin Adamski,,
- Software Department
, Irina Kowalska
Irina Kowalska,,
-
Journal seriesEndocrine, ISSN 1355-008X, [0969-711X], (N/A 100 pkt)
Issue year2019
Vol65
No1
Pages184-191
Publication size in sheets0.5
Keywords in EnglishThyroid PCOS Lipids
ASJC Classification2712 Endocrinology, Diabetes and Metabolism; 1310 Endocrinology
DOIDOI:10.1007/s12020-019-01913-0
Internal identifier000045371
Languageen angielski
LicenseJournal (articles only); published final; Other open licence; with publication
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 11-03-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.009; WoS Impact Factor: 2018 = 3.296 (2) - 2018=2.941 (5)
Citation count*
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back
Confirmation
Are you sure?